GtoPdb Ligand ID: 2299

Comment: The US FDA granted approval for the use of an injectable formulation of ethanol (alcohol) in dextrose solution, but marketing has been discontinued.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 20.23
Molecular weight 46.04
XLogP -0.08
No. Lipinski's rules broken 0
Canonical SMILES CCO
InChI InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
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A discrete alcohol pocket involved in GIRK channel activation.
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Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity.
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Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine3A receptor alter gating and alcohol modulatory actions.
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Ethanol opens G-protein-activated inwardly rectifying K+ channels.
Nat. Neurosci., 2 (12): 1091-7. [PMID:10570486]
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G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action.
Nat. Neurosci., 2 (12): 1084-90. [PMID:10570485]
7. Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, Harris RA. (1996)
A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.
Mol. Pharmacol., 50 (2): 402-6. [PMID:8700149]
8. Zhou Q, Verdoorn TA, Lovinger DM. (1998)
Alcohols potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state.
J. Physiol. (Lond.), 507 ( Pt 2): 335-52. [PMID:9518697]