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Compound class: Metabolite or derivative
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Ishihara K, Hiraoka M, Ochi R. (1996)
The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells.
J Physiol (Lond.), 491 ( Pt 2): 367-81. [PMID:8866861]
2. Lopatin AN, Makhina EN, Nichols CG. (1994)
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification.
Nature, 372 (6504): 366-9. [PMID:7969496]
3. Quinn SJ, Ye CP, Diaz R, Kifor O, Bai M, Vassilev P, Brown E. (1997)
The Ca2+-sensing receptor: a target for polyamines.
Am J Physiol, 273 (4): C1315-23. [PMID:9357776]
4. Yang J, Jan YN, Jan LY. (1995)
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
Neuron, 14 (5): 1047-54. [PMID:7748552]