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Synonyms: cyclic ADP ribose
Compound class: Metabolite or derivative
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Beck A, Kolisek M, Bagley LA, Fleig A, Penner R. (2006)
Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes.
FASEB J., 20 (7): 962-4. [PMID:16585058]
2. Kolisek M, Beck A, Fleig A, Penner R. (2005)
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels.
Mol. Cell, 18 (1): 61-9. [PMID:15808509]
3. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M. (2006)
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.
EMBO J., 25 (9): 1804-15. [PMID:16601673]