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Compound class: Metabolite or derivative
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, Fournier B. (2002)
X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha.
Structure, 10 (12): 1697-707. [PMID:12467577]
2. Noshiro M, Okuda K. (1990)
Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.
FEBS Lett, 268 (1): 137-40. [PMID:2384150]
3. Paravicini G, Steinmayr M, André E, Becker-André M. (1996)
The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.
Biochem Biophys Res Commun, 227 (1): 82-7. [PMID:8858107]