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Synonyms: Calcijex® | calcitriol | Rocaltrol®
1,25-dihydroxyvitamin D3 is an approved drug (FDA (1978))
Compound class: Metabolite or derivative
Comment: Vitamin D receptor agonist. Calcitrol is the active form of vitamin D found in the body.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: calcitrol
1. Bishop JE, Collins ED, Okamura WH, Norman AW. (1994)
Profile of ligand specificity of the vitamin D binding protein for 1 alpha,25-dihydroxyvitamin D3 and its analogs.
J Bone Miner Res, 9 (8): 1277-88. [PMID:7976510]
2. Erben RG, Soegiarto DW, Weber K, Zeitz U, Lieberherr M, Gniadecki R, Möller G, Adamski J, Balling R. (2002)
Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D.
Mol Endocrinol, 16 (7): 1524-37. [PMID:12089348]