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Compound class: Endogenous peptide in human, mouse or rat
Comment: Rat secretin differs in sequence from pig, mouse and human
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Dong M, Wang Y, Hadac EM, Pinon DI, Holicky E, Miller LJ. (1999)
Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor.
J. Biol. Chem., 274 (27): 19161-7. [PMID:10383421]
2. Ganguli SC, Park CG, Holtmann MH, Hadac EM, Kenakin TP, Miller LJ. (1998)
Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis.
J. Pharmacol. Exp. Ther., 286 (2): 593-8. [PMID:9694908]