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Synonyms: m1-toxin 1 | MT7 | recombinant mamba venom toxin | rMT7 
Compound class: Peptide or derivative
Comment: Recombinant MT7 (rMT7) is often used for bioassays due to the limited availability of the M1 muscarinic receptor-selective mamba toxin MT7  or m1-toxin 1 (rMT7 has comparable affinity for M1 )
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bradley KN. (2000)
Muscarinic toxins from the green mamba.
Pharmacol Ther, 85 (2): 87-109. [PMID:10722122]
2. Fruchart-Gaillard C, Mourier G, Marquer C, Ménez A, Servent D. (2006)
Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.
Mol Pharmacol, 69 (5): 1641-51. [PMID:16439611]
3. Näsman J, Jolkkonen M, Ammoun S, Karlsson E, Akerman KE. (2000)
Recombinant expression of a selective blocker of M(1) muscarinic receptors.
Biochem Biophys Res Commun, 271 (2): 435-9. [PMID:10799315]
4. Olianas MC, Maullu C, Adem A, Mulugeta E, Karlsson E, Onali P. (2000)
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
Br J Pharmacol, 131 (3): 447-52. [PMID:11015294]