muscarinic toxin 7   Click here for help

GtoPdb Ligand ID: 314

Synonyms: m1-toxin 1 | MT7 | recombinant mamba venom toxin | rMT7 [3]
Comment: Recombinant MT7 (rMT7) is often used for bioassays due to the limited availability of the M1 muscarinic receptor-selective mamba toxin MT7 [1] or m1-toxin 1 (rMT7 has comparable affinity for M1 [3])
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1. Bradley KN. (2000)
Muscarinic toxins from the green mamba.
Pharmacol Ther, 85 (2): 87-109. [PMID:10722122]
2. Fruchart-Gaillard C, Mourier G, Marquer C, Ménez A, Servent D. (2006)
Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.
Mol Pharmacol, 69 (5): 1641-51. [PMID:16439611]
3. Näsman J, Jolkkonen M, Ammoun S, Karlsson E, Akerman KE. (2000)
Recombinant expression of a selective blocker of M(1) muscarinic receptors.
Biochem Biophys Res Commun, 271 (2): 435-9. [PMID:10799315]
4. Olianas MC, Maullu C, Adem A, Mulugeta E, Karlsson E, Onali P. (2000)
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
Br J Pharmacol, 131 (3): 447-52. [PMID:11015294]