endomorphin-2   Click here for help

GtoPdb Ligand ID: 3668

Comment: The amino acid sequence for endomorphin-2 is believed to be common to all mammalian species [2]

An endogenous peptide, the gene encoding the endomorphin precursor has not yet been identified [1].
Species: Human
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES Oc1ccc(cc1)CC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc1ccccc1)N
Isomeric SMILES Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)Cc1ccccc1)N
InChI InChI=1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1
InChI Key XIJHWXXXIMEHKW-LJWNLINESA-N
References
1. Rónai AZ, Király K, Szebeni A, Szemenyei E, Prohászka Z, Darula Z, Tóth G, Till I, Szalay B, Kató E et al.. (2009)
Immunoreactive endomorphin 2 is generated extracellularly in rat isolated L4,5 dorsal root ganglia by DPP-IV.
Regul Pept, 157 (1-3): 1-2. [PMID:19540879]
2. Zadina JE, Hackler L, Ge LJ, Kastin AJ. (1997)
A potent and selective endogenous agonist for the mu-opiate receptor.
Nature, 386 (6624): 499-502. [PMID:9087409]