Synonyms: IRL 1620 | IRL-1620 | IRL2620 | PMZ-1620 | SPI-1620 | Suc[Glu9,Ala11,15]ET-110-21 | Tycamzzi®
sovateltide is an approved drug (India CDSCO (2023))
Compound class:
Peptide
Comment: Sovateltide (previously IRL-1620 and PMZ-1620) is a selective endothelin-B receptor (ETB) agonist. It is proposed as a mechanism to improve formation of new mature neurons and blood vessels in acute cerebral ischemia [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Gulati A, Agrawal N, Vibha D, Misra UK, Paul B, Jain D, Pandian J, Borgohain R. (2021)
Safety and Efficacy of Sovateltide (IRL-1620) in a Multicenter Randomized Controlled Clinical Trial in Patients with Acute Cerebral Ischemic Stroke. CNS Drugs, 35 (1): 85-104. [PMID:33428177] |
2. Keam SJ. (2023)
Sovateltide: First Approval. Drugs, 83 (13): 1239-1244. [PMID:37486545] |
3. Ranjan AK, Gulati A. (2022)
Sovateltide Mediated Endothelin B Receptors Agonism and Curbing Neurological Disorders. Int J Mol Sci, 23 (6). [PMID:35328566] |
4. Watakabe T, Urade Y, Takai M, Umemura I, Okada T. (1992)
A reversible radioligand specific for the ETB receptor: [125I]Tyr13-Suc-[Glu9,Ala11,15]-endothelin-1(8- 21), [125I]IRL 1620. Biochem Biophys Res Commun, 185 (3): 867-73. [PMID:1320877] |