calciseptine   Click here for help

GtoPdb Ligand ID: 4149

Comment: From the venom gland of Dendroaspis polylepis polylepis (Black mamba)
Click here for help
1. Barrere C, Chinda K, Mesirca P, Aurelie C, Diochot S, Lazdunsk M, Barrere-Lamaire S, Mangoni M, Nargeot J. (2020)
Evidence for a selective blockade of Cav1.2 versus Cav1.3 by the mamba toxin calciseptine in the mouse heart.
Archives of Cardiovascular Diseases Supplements, 12 (2-4): 259. DOI: 10.1016/j.acvdsp.2020.03.144
2. de Weille JR, Schweitz H, Maes P, Tartar A, Lazdunski M. (1991)
Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel.
Proc Natl Acad Sci U S A, 88 (6): 2437-40. [PMID:1848702]
3. Watanabe TX, Itahara Y, Kuroda H, Chen YN, Kimura T, Sakakibara S. (1995)
Smooth muscle relaxing and hypotensive activities of synthetic calciseptine and the homologous snake venom peptide FS2.
Jpn J Pharmacol, 68 (3): 305-13. [PMID:7474554]