Synonyms: ferroheme | haem
Compound class:
Metabolite
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Duffy SP, Shing J, Saraon P, Berger LC, Eiden MV, Wilde A, Tailor CS. (2010)
The Fowler syndrome-associated protein FLVCR2 is an importer of heme. Mol Cell Biol, 30 (22): 5318-24. [PMID:20823265] |
2. Matta-Camacho E, Banerjee S, Hughes TS, Solt LA, Wang Y, Burris TP, Kojetin DJ. (2014)
Structure of REV-ERBĪ² ligand-binding domain bound to a porphyrin antagonist. J Biol Chem, 289 (29): 20054-66. [PMID:24872411] |
3. Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H. (2007)
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther, 322 (2): 469-76. [PMID:17475902] |
4. Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL. (2004)
Identification of a human heme exporter that is essential for erythropoiesis. Cell, 118 (6): 757-66. [PMID:15369674] |
5. Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F. (2007)
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol, 14 (12): 1207-13. [PMID:18037887] |
6. Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB et al.. (2007)
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science, 318 (5857): 1786-9. [PMID:18006707] |