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Synonyms: C motif cytokine 2 | lymphotactin β
Compound class:
Endogenous peptide in human, mouse or rat
Comment: XCL2 is a C subfamily chemokine, closely related to XCL1. It alternates between monomeric and dimeric states under physiological NaCl and temperature conditions. The monomeric form activates its G protein-coupled receptor XCR1, and the dimeric form is important for glycosaminoglycan (GAG) binding [1].
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Fox JC, Nakayama T, Tyler RC, Sander TL, Yoshie O, Volkman BF. (2015)
Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily. Cytokine, 71 (2): 302-11. [PMID:25497737] |
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2. Kim M, Rooper L, Xie J, Rayahin J, Burdette JE, Kajdacsy-Balla AA, Barbolina MV. (2012)
The lymphotactin receptor is expressed in epithelial ovarian carcinoma and contributes to cell migration and proliferation. Mol Cancer Res, 10 (11): 1419-29. [PMID:22964431] |
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3. Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O. (1998)
Identification of single C motif-1/lymphotactin receptor XCR1. J Biol Chem, 273 (26): 16551-4. [PMID:9632725] |
