folic acid

Ligand id: 4563

Name: folic acid

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 6
Rotatable bonds 10
Topological polar surface area 213.28
Molecular weight 441.14
XLogP -1.88
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H. (2007)
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
J. Pharmacol. Exp. Ther., 322 (2): 469-76. [PMID:17475902]
2. Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V. (1995)
Molecular cloning of the human placental folate transporter.
Biochem. Biophys. Res. Commun., 206 (2): 681-7. [PMID:7826387]