AF12198   Click here for help

GtoPdb Ligand ID: 4861

Synonyms: AF 12198 | AF-12198
Immunopharmacology Ligand
Comment: Potent, selective human type I IL-1 receptor antagonist
1. Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW et al.. (1996)
AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1.
J Biol Chem, 271 (48): 30517-23. [PMID:8940020]