thymic stromal lymphopoietin   Click here for help

GtoPdb Ligand ID: 5083

Abbreviated name: TSLP
Immunopharmacology Ligand
Comment: Thymic stromal lymphopoietin (TLSP), an IL-7 like cytokine, is the endogenous ligand for the TLSP receptor. TLSP/TLSPR signalling is pro-inflammatory.
Species: Human
1. Corren J, Ziegler SF. (2019)
TSLP: from allergy to cancer.
Nat Immunol, 20 (12): 1603-1609. [PMID:31745338]
2. Gauvreau GM, O'Byrne PM, Boulet LP, Wang Y, Cockcroft D, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C et al.. (2014)
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses.
N Engl J Med, 370 (22): 2102-10. [PMID:24846652]
3. Han NR, Oh HA, Nam SY, Moon PD, Kim DW, Kim HM, Jeong HJ. (2014)
TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6.
J Invest Dermatol, 134 (10): 2521-30. [PMID:24751726]
4. Migalovich-Sheikhet H, Friedman S, Mankuta D, Levi-Schaffer F. (2012)
Novel identified receptors on mast cells.
Front Immunol, 3: 238. [PMID:22876248]
5. Sano Y, Masuda K, Tamagawa-Mineoka R, Matsunaka H, Murakami Y, Yamashita R, Morita E, Katoh N. (2013)
Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis.
Clin Exp Immunol, 171 (3): 330-7. [PMID:23379440]
6. Shikotra A, Choy DF, Ohri CM, Doran E, Butler C, Hargadon B, Shelley M, Abbas AR, Austin CD, Jackman J et al.. (2012)
Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.
J Allergy Clin Immunol, 129 (1): 104-11.e1-9. [PMID:21975173]
7. Wong CK, Hu S, Cheung PF, Lam CW. (2010)
Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation.
Am J Respir Cell Mol Biol, 43 (3): 305-15. [PMID:19843704]