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Compound class: Endogenous peptide in human, mouse or rat
Comment: Alarin is a splice variant of GALP. This variant excludes exon 3 and results in a frame shift leading to a stop codon after 49 amino acids. The C terminal 25 amino acids are predicted to constitute the fully processed, mature peptide .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Boughton CK, Patterson M, Bewick GA, Tadross JA, Gardiner JV, Beale KE, Chaudery F, Hunter G, Busbridge M, Leavy EM et al.. (2010)
Alarin stimulates food intake and gonadotrophin release in male rats.
Br J Pharmacol, 161 (3): 601-13. [PMID:20880399]
2. Santic R, Schmidhuber SM, Lang R, Rauch I, Voglas E, Eberhard N, Bauer JW, Brain SD, Kofler B. (2007)
Alarin is a vasoactive peptide.
Proc Natl Acad Sci USA, 104 (24): 10217-22. [PMID:17535903]