abatacept   Click here for help

GtoPdb Ligand ID: 6891

Synonyms: BMS-188667 | CTLA4-IgG4m | Orencia® | RG-1046 | RG-2077
Approved drug Immunopharmacology Ligand
abatacept is an approved drug (FDA (2005), EMA (2005))
Comment: Abatacept is a recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) [3]. In essence, abatacept is a CTLA-4 mimetic, that enhances CTLA-4's inhibitory signal to T cells, thereby down-modulating T cell mediated inflammation.
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Immunotherapies currently in development for the treatment of type 1 diabetes.
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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
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CTLA-4 is a second receptor for the B cell activation antigen B7.
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Therapies to Preserve ╬▓-Cell Function in Type 1 Diabetes.
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5. Vicente Rabaneda EF, Herrero-Beaumont G, Casta├▒eda S. (2013)
Update on the use of abatacept for the treatment of rheumatoid arthritis.
Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]