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Synonyms: 17α-ethynylestradiol | ethinyl estradiol
ethinylestradiol is an approved drug
Compound class: Metabolite or derivative
Comment: Ethinylestradiol is contained in a large number of combined oral contraceptive formulations and HRT medications. Use of ethinylestradiol, unapposed by a progestin, increases the risk of endometrial cancer.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: ethinylestradiol
1. Jain N, Kanojia RM, Xu J, Jian-Zhong G, Pacia E, Lai MT, Du F, Musto A, Allan G, Hahn D et al.. (2006)
Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness.
J Med Chem, 49 (11): 3056-9. [PMID:16722623]