daratumumab   Click here for help

GtoPdb Ligand ID: 7395

Synonyms: 3003-005 | Darzalex® | HuMax-CD38 | JNJ-54767414
Approved drug Immunopharmacology Ligand
daratumumab is an approved drug (FDA (2015), EMA (2017))
Compound class: Antibody
Comment: Daratumumab is a monoclonal antibody directed against CD38.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. De Weers M, Graus Y, Oprins J, Parren P, Van De Winkel J, Van Vugt M. (2010)
Antibodies Against Cd38 For Treatment Of Multiple Myeloma.
Patent number: US7829673. Assignee: Genmab A/S. Priority date: 23/03/2005. Publication date: 09/11/2010.
2. de Weers M, Tai YT, van der Veer MS, Bakker JM, Vink T, Jacobs DC, Oomen LA, Peipp M, Valerius T, Slootstra JW et al.. (2011)
Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.
J Immunol, 186 (3): 1840-8. [PMID:21187443]
3. van der Veer MS, de Weers M, van Kessel B, Bakker JM, Wittebol S, Parren PW, Lokhorst HM, Mutis T. (2011)
The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies.
Blood Cancer J, 1 (10): e41. [PMID:22829073]
4. van der Veer MS, de Weers M, van Kessel B, Bakker JM, Wittebol S, Parren PW, Lokhorst HM, Mutis T. (2011)
Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumab.
Haematologica, 96 (2): 284-90. [PMID:21109694]
5. (2016)
A Three-Drug Combo for Multiple Myeloma.
Cancer Discov, 6 (11): OF4. [PMID:27630127]