brodalumab   Click here for help

GtoPdb Ligand ID: 7540

Synonyms: AMG-827 | AMG827 | Kyntheum® | Lumicef® | Siliq®
Approved drug Immunopharmacology Ligand
brodalumab is an approved drug (Japan (2016), FDA (2017), EMA (2017))
Compound class: Antibody
Comment: Brodalumab is a human monoclonal antibody designed for the treatment of inflammatory diseases. It targets the interleukin 17 receptor A (IL17RA).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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1. Chiricozzi A. (2014)
Pathogenic role of IL-17 in psoriasis and psoriatic arthritis.
Actas Dermosifiliogr, 105 Suppl 1: 9-20. [PMID:25398488]
2. Girolomoni G, Mrowietz U, Paul C. (2012)
Psoriasis: rationale for targeting interleukin-17.
Br J Dermatol, 167 (4): 717-24. [PMID:22716185]
3. Krueger JG, Fretzin S, Suárez-Fariñas M, Haslett PA, Phipps KM, Cameron GS, McColm J, Katcherian A, Cueto I, White T et al.. (2012)
IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis.
J Allergy Clin Immunol, 130 (1): 145-54.e9. [PMID:22677045]
4. Mease PJ, Genovese MC, Greenwald MW, Ritchlin CT, Beaulieu AD, Deodhar A, Newmark R, Feng J, Erondu N, Nirula A. (2014)
Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis.
N Engl J Med, 370 (24): 2295-2306. [PMID:24918373]
5. Mullard A. (2017)
New plaque psoriasis approval carries suicide warning.
Nat Rev Drug Discov, 16 (3): 155. [PMID:28248935]
6. Russell CB, Rand H, Bigler J, Kerkof K, Timour M, Bautista E, Krueger JG, Salinger DH, Welcher AA, Martin DA. (2014)
Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti-IL-17 receptor monoclonal antibody.
J Immunol, 192 (8): 3828-36. [PMID:24646743]
7. Tocker J, Mehlin C, Lim AC. (2010)
Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto.
Patent number: US7767206. Assignee: Amgen Inc.. Priority date: 02/10/2006. Publication date: 03/08/2010.