CCL11   Click here for help

GtoPdb Ligand ID: 769

Synonyms: eotaxin
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL11 (commonly refered to as eotaxin) is an eosinophil chemotactic chemokine.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Blanpain C, Migeotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, Vassart G, Doms RW, Parmentier M. (1999)
CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.
Blood, 94 (6): 1899-905. [PMID:10477718]
2. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS. (1996)
Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
J Exp Med, 183 (5): 2349-54. [PMID:8642344]
3. Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA. (2003)
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.
Genes Immun, 4 (4): 245-50. [PMID:12761559]
4. Kitaura M, Suzuki N, Imai T, Takagi S, Suzuki R, Nakajima T, Hirai K, Nomiyama H, Yoshie O. (1999)
Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3.
J Biol Chem, 274 (39): 27975-80. [PMID:10488147]
5. Lüttichau HR, Clark-Lewis I, Jensen PØ, Moser C, Gerstoft J, Schwartz TW. (2003)
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
J Biol Chem, 278 (13): 10928-33. [PMID:12554737]
6. Morokata T, Suzuki K, Masunaga Y, Taguchi K, Morihira K, Sato I, Fujii M, Takizawa S, Torii Y, Yamamoto N et al.. (2006)
A novel, selective, and orally available antagonist for CC chemokine receptor 3.
J Pharmacol Exp Ther, 317 (1): 244-50. [PMID:16339911]
7. Parody TR, Stone MJ. (2004)
High level expression, activation, and antagonism of CC chemokine receptors CCR2 and CCR3 in Chinese hamster ovary cells.
Cytokine, 27 (1): 38-46. [PMID:15207250]
8. Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ, Pease JE. (2000)
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
J Biol Chem, 275 (34): 25985-92. [PMID:10854442]
9. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA. (1997)
High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
J Clin Invest, 100 (5): 1137-43. [PMID:9276730]
10. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]
11. Zhang J, Lathbury LJ, Salamonsen LA. (2000)
Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.
Biol Reprod, 62 (2): 404-11. [PMID:10642580]