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Synonyms: ckβ9 | TCA-4
Compound class:
Endogenous peptide in human, mouse or rat
Comment: CCL21 is a CC family chemokine. It has a unique six conserved cysteine residue structure instead of the four typical of other chemokines.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Nguyen T, Lagman C, Chung LK, Chen CH, Poon J, Ong V, Voth BL, Yang I. (2017)
Insights into CCL21's roles in immunosurveillance and immunotherapy for gliomas. J Neuroimmunol, 305: 29-34. [PMID:28284342] |
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2. Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ et al.. (2013)
β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. J Biol Chem, 288 (10): 7169-81. [PMID:23341447] |
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3. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O. (1998)
Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J Biol Chem, 273: 7118-7122. [PMID:9507024] |
