dezamizumab   Click here for help

GtoPdb Ligand ID: 8255

Synonyms: GSK-2398852 | GSK2398852
Compound class: Antibody
Comment: Dezamizumab (GSK2398852) is an anti-human serum amyloid P component (anti-SAP) monoclonal antibody, being developed by GlaxoSmithKline as a potential therapy for the rare disease amyloidosis.
1. Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ et al.. (2010)
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
Nature, 468 (7320): 93-7. [PMID:20962779]
2. Botto M, Hawkins PN, Bickerstaff MC, Herbert J, Bygrave AE, McBride A, Hutchinson WL, Tennent GA, Walport MJ, Pepys MB. (1997)
Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene.
Nat Med, 3 (8): 855-9. [PMID:9256275]
3. Tennent GA, Lovat LB, Pepys MB. (1995)
Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.
Proc Natl Acad Sci USA, 92 (10): 4299-303. [PMID:7753801]