milatuzumab   Click here for help

GtoPdb Ligand ID: 8267

Synonyms: hLL1 | IMMU-115
Immunopharmacology Ligand
Compound class: Antibody
Comment: Milatuzumab is a humanized monoclonal antibody targeting CD74, a cell surface molecule which links the innate and adaptive immune responses by regulating the survival of macrophages and B cells. CD74 is also known as the invariant chain of major histocompatibility complex class II and acts as a receptor for macrophage migration inhibitory factor (MIF).
Milatuzumab may also be conjugated with doxorubicin creating the antibody-drug conjugate (ADC) hLL1-DOX (aka IMMU-110) [1].
Peptide sequence information for this antibody is available from its IMGT/mAb-DB link.
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1. Sapra P, Stein R, Pickett J, Qu Z, Govindan SV, Cardillo TM, Hansen HJ, Horak ID, Griffiths GL, Goldenberg DM. (2005)
Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys.
Clin Cancer Res, 11 (14): 5257-64. [PMID:16033844]
2. Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, Govindan S, Goldenberg DM. (2007)
CD74: a new candidate target for the immunotherapy of B-cell neoplasms.
Clin Cancer Res, 13 (18 Pt 2): 5556s-5563s. [PMID:17875789]