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Compound class:
Peptide or derivative
Comment: Synthetic analogue of human INSL3, comprising an A and a B chain. The sequence of the B chain is the same as that of natural ligand and is shown on the ligand page for INSL3 (B chain), while the sequence of the A chain is shown on the 'structure' tab. The reference describing the synthesis of this peptide includes a figure respresenting the structure including disulphide bond formation between the chains
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Zhang S, Hughes RA, Bathgate RA, Shabanpoor F, Hossain MA, Lin F, van Lierop B, Robinson AJ, Wade JD. (2010)
Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2. Peptides, 31 (9): 1730-6. [PMID:20570702] |
