IFN-γ1b (human recombinant)

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Ligands
IFN-γ1b (human recombinant)

GtoPdb Ligand ID: 8341

Synonyms: Actimmune®. | IFNγ2a

IFN-γ1b (human recombinant) is an approved drug (FDA (1999))

Compound class: Peptide or derivative

Comment: This is a recombinant analogue of human interferon gamma (IFN-γ) produced in E.coli and is therefore not glycosylated.

References
1. Boehm U, Klamp T, Groot M, Howard JC. (1997) Cellular responses to interferon-gamma. Annu Rev Immunol, 15: 749-95. [PMID:9143706]
2. Key Jr LL, Rodriguiz RM, Willi SM, Wright NM, Hatcher HC, Eyre DR, Cure JK, Griffin PP, Ries WL. (1995) Long-term treatment of osteopetrosis with recombinant human interferon gamma. N Engl J Med, 332 (24): 1594-9. [PMID:7753137]
3. No authors listed. (1991) A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. The International Chronic Granulomatous Disease Cooperative Study Group. N Engl J Med, 324 (8): 509-16. [PMID:1846940]
4. Seyer L, Greeley N, Foerster D, Strawser C, Gelbard S, Dong Y, Schadt K, Cotticelli MG, Brocht A, Farmer J et al.. (2015) Open-label pilot study of interferon gamma-1b in Friedreich ataxia. Acta Neurol Scand, 132 (1): 7-15. [PMID:25335475]
5. Tau G, Rothman P. (1999) Biologic functions of the IFN-gamma receptors. Allergy, 54 (12): 1233-51. [PMID:10688427]

References

1. Boehm U, Klamp T, Groot M, Howard JC. (1997)
Cellular responses to interferon-gamma.
Annu Rev Immunol, 15: 749-95. [PMID:9143706]

2. Key Jr LL, Rodriguiz RM, Willi SM, Wright NM, Hatcher HC, Eyre DR, Cure JK, Griffin PP, Ries WL. (1995)
Long-term treatment of osteopetrosis with recombinant human interferon gamma.
N Engl J Med, 332 (24): 1594-9. [PMID:7753137]

3. No authors listed. (1991)
A controlled trial of interferon gamma to prevent infection in chronic granulomatous disease. The International Chronic Granulomatous Disease Cooperative Study Group.
N Engl J Med, 324 (8): 509-16. [PMID:1846940]

4. Seyer L, Greeley N, Foerster D, Strawser C, Gelbard S, Dong Y, Schadt K, Cotticelli MG, Brocht A, Farmer J et al.. (2015)
Open-label pilot study of interferon gamma-1b in Friedreich ataxia.
Acta Neurol Scand, 132 (1): 7-15. [PMID:25335475]

5. Tau G, Rothman P. (1999)
Biologic functions of the IFN-gamma receptors.
Allergy, 54 (12): 1233-51. [PMID:10688427]