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Compound class: Peptide or derivative
Comment: PWT1-NPS is a tetrabranched derivative of human neuropeptide S (hNPS), which is suitable for in vitro and in vivo investigations . Its structure consists of a chemical core linking 4 hNPS peptides. PWT stands for peptide welding technology (see patent WO2014161926 for further details ).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Guerrini R, Salvadori S, Calo G. (2015)
Supramolecular aggregates comprising maleimido cores.
Patent number: WO2014161926. Assignee: Ufpeptides S.R.L.. Priority date: 05/04/2013. Publication date: 23/12/2015.
2. Ruzza C, Rizzi A, Malfacini D, Pulga A, Pacifico S, Salvadori S, Trapella C, Reinscheid RK, Calo G, Guerrini R. (2015)
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.
Pharmacol Res Perspect, 3 (1): e00108. [PMID:25692025]