urocortin 1   Click here for help

GtoPdb Ligand ID: 920

Comment: The human UCN sequence differs from the mouse and rat sequences at residues 2 and 4 representing asparagine and serine, respectively. The mouse and rat sequences are identical.
Species: Mouse, Rat
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References
1. Dautzenberg FM, Py-Lang G, Higelin J, Fischer C, Wright MB, Huber G. (2001)
Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences.
J Pharmacol Exp Ther, 296 (1): 113-20. [PMID:11123370]
2. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. (1996)
Cloning and characterization of human urocortin.
Endocrinology, 137 (5): 2167-70. [PMID:8612563]
3. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W et al.. (2001)
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.
Proc Natl Acad Sci USA, 98 (13): 7570-5. [PMID:11416224]
4. Perrin MH, Sutton SW, Cervini LA, Rivier JE, Vale WW. (1999)
Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors.
J Pharmacol Exp Ther, 288 (2): 729-34. [PMID:9918582]
5. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C et al.. (1995)
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.
Nature, 378 (6554): 287-92. [PMID:7477349]