urocortin 1   Click here for help

GtoPdb Ligand ID: 920

Compound class: Endogenous peptide in human, mouse or rat
Comment: The human UCN sequence differs from the mouse and rat sequences at residues 2 and 4 representing asparagine and serine, respectively. The mouse and rat sequences are identical.
Species: Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Dautzenberg FM, Py-Lang G, Higelin J, Fischer C, Wright MB, Huber G. (2001)
Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences.
J Pharmacol Exp Ther, 296 (1): 113-20. [PMID:11123370]
2. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. (1996)
Cloning and characterization of human urocortin.
Endocrinology, 137 (5): 2167-70. [PMID:8612563]
3. Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W et al.. (2001)
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.
Proc Natl Acad Sci USA, 98 (13): 7570-5. [PMID:11416224]
4. Perrin MH, Sutton SW, Cervini LA, Rivier JE, Vale WW. (1999)
Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors.
J Pharmacol Exp Ther, 288 (2): 729-34. [PMID:9918582]
5. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C et al.. (1995)
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.
Nature, 378 (6554): 287-92. [PMID:7477349]