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Compound class:
Peptide or derivative
Comment: This is insulin-like peptide 5 (INSL5) analogue 7 with single-point substitution T9R [1]. It is the minimal sequence required to retain INSL5 mimetic activity. Like ghrelin, INSL5 is an orexigenic gut hormone that plays a physiological role in driving food intake. INSL5 acts via the relaxin family peptide receptor 4 (RXFP4). INSL5 mimetics are being investigated for their potential to provide clinical benefit in the treatment of anorexia.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Patil NA, Hughes RA, Rosengren KJ, Kocan M, Ang SY, Tailhades J, Separovic F, Summers RJ, Grosse J, Wade JD et al.. (2016)
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist. J Med Chem, 59 (5): 2118-25. [PMID:26824523] |
