μ-conotoxin GIIIA   Click here for help

GtoPdb Ligand ID: 2630

Synonyms: Geographutoxin I | GTx-I | Myotoxin I
Compound class: Peptide or derivative
Comment: From Conus geographus (Geography cone)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Peptide Sequence Click here for help
RDCCTPPKKCKDRQCKPQRCCA
Arg-Asp-Cys-Cys-Thr-Pro-Pro-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Pro-Gln-Arg-Cys-Cys-Ala-NH2
Post-translational Modification
Proline residues at positions 6 and 7 are partially hydroxylated; proline residue at position 17 undergoes full hydroxylation; C-terminal alanine residue undergoes amidation; disulphide bond formation between cysteine residues at positions 3 and 15, 4 and 20, and 10 and 21.