IL-12B

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Ligands
IL-12B (Human)

GtoPdb Ligand ID: 5002

Synonyms: IL-12 p40 | IL-12B monomer | interleukin-12β | interleukin-12B | natural killer cell stimulatory factor 2

Compound class: Endogenous peptide in human, mouse or rat

Comment: This is a subunit of bioactive IL-12.

Species: Human

Is a component of
IL-12
IL-23

Is a component of

IL-12

IL-23

Peptide Sequence
IWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLL LLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRG DNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTW STPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS

Post-translational Modification
N-linked glycosylation of asparagine residue at position 100; C-linked glycosylation of tryptophan at position 297, and disulphide bond formation between cysteine residues at positions 28 and 68, 109 and 120, 148 and 171, and 278 and 305. Predicted N-linked glycosylation of aspragibe at position 113. In the IL12A/Il12B heteromer there is an interchain disulphide bond between cysteine residues at positions 177 of the beta chain and 74 in the alpha chain.

Post-translational Modification

N-linked glycosylation of asparagine residue at position 100; C-linked glycosylation of tryptophan at position 297, and disulphide bond formation between cysteine residues at positions 28 and 68, 109 and 120, 148 and 171, and 278 and 305. Predicted N-linked glycosylation of aspragibe at position 113. In the IL12A/Il12B heteromer there is an interchain disulphide bond between cysteine residues at positions 177 of the beta chain and 74 in the alpha chain.