TL6   Click here for help

GtoPdb Ligand ID: 5072

Synonyms: activation-inducible TNF-related ligand | glucocorticoid- induced TNF-related ligand
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TL6 (official name, tumor necrosis factor ligand superfamily member 18) is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is thought to be involved in T cell interactions with endothelial cells, via binding to its receptor TNFRSF18 (a.k.a. AITR and GITR).
Species: Human
Peptide Sequence Click here for help
MTLHPSPITCEFLFSTALISPKMCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPC
MAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGG
TYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
Selected 3D Structures
PDB Id: 2Q1M
Image of ligand 3D structure from RCSB PDB
Post-translational Modification
Predicted N-linked glycosylation of asparagine residues at positions 151 and 183; disulphide bond formation between cysteine residues at positions 80 and 100