[Ala1,12,Aib3,Gln10,hArg11,Trp14,Arg19]PTH-(1-34)-NH2   Click here for help

GtoPdb Ligand ID: 5573

Synonyms: [Ala1,12,Aib3,Gln10,hArg11,Trp14,Arg19]-hPTH 1-34-NH2 | M-PTH(1-34)
Compound class: Peptide or derivative
Comment: Synthetic analogue of human PTH
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Peptide Sequence Click here for help
AVXEIQLMHQXAKWLNSMRRVEWLRKKLQDVHNF
Ala-Val-Aib-Glu-Ile-Gln-Leu-Met-His-Gln-Har-Ala-Lys-Trp-Leu-Asn-Ser-Met-Arg-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-NH2
Chemical Modification
Serine residue 1 and glycine residue 12 of the natural sequence are replaced by alanine residues, serine resdiue 3 is replaced by α-aminoisobutyric acid (Aib); asparagine resdiue 10 is replaced by glutamine, leucine residue 11 by homoarginine (Har), histidine residue 14 by tryptophan and glutamic acid residue 19 by arginine. C-terminal phenylalanine residue is amidated