AL-78898A   Click here for help

GtoPdb Ligand ID: 9219

Synonyms: 4(1MeW) [2] | POT-4
Immunopharmacology Ligand
Compound class: Peptide or derivative
Comment: AL-78898A is an investigational analogue of compstatin [2], which acts as an irreversible inhibitor of complement component 3 (C3). C3 inhibitors are being actively investigated for clinical potential in inflammatory and degenerative diseases [1].
Peptide Sequence Click here for help
Ac-Ile-[Cys-Val-Trp(Me)-Gln-Asp-Trp-Gly-His-His-Arg-Cys]-Thr-NH2
Chemical Modification
Acetylated amino terminal and amidated carboxy terminal. Cys2-Cys12 forms disulphide bond. Trp4 is methylated.