L-ascorbic acid   Click here for help

GtoPdb Ligand ID: 4781

Synonyms: vitamin C
PDB Ligand
Compound class: Metabolite
Comment: Used as a nutritional supplement to treat vitamin C deficiency (scurvy) and to help promote wound and bone healing.

L-ascorbic acid is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 107.22
Molecular weight 176.03
XLogP -0.18
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OCC(C1OC(=O)C(=C1O)O)O
Isomeric SMILES OC[C@@H]([C@H]1OC(=O)C(=C1O)O)O
InChI InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChI Key CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Metabolite
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
(5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
International Nonproprietary Names Click here for help
INN number INN
372 ascorbic acid
Synonyms Click here for help
vitamin C
Database Links Click here for help
CAS Registry No. 50-81-7 (source: Scifinder)
ChEBI CHEBI:29073
ChEMBL Ligand CHEMBL196
DrugBank Ligand DB00126
DrugCentral Ligand 4072, 4072
GtoPdb PubChem SID 178101483
PubChem CID 54670067
RCSB PDB Ligand ASC
Search Google for chemical match using the InChIKey CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Search Google for chemicals with the same backbone CIWBSHSKHKDKBQ
Search PubMed clinical trials ascorbic acid
Search PubMed titles ascorbic acid
Search PubMed titles/abstracts ascorbic acid
UniChem Compound Search for chemical match using the InChIKey CIWBSHSKHKDKBQ-JLAZNSOCSA-N
UniChem Connectivity Search for chemical match using the InChIKey CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Wikipedia Ascorbic_acid

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MedChemExpress
L-Ascorbic acid (links to external site)
Cat. No. HY-B0166
L-Ascorbic acid (GMP Like) (links to external site)
Cat. No. HY-B0166GL
L-Ascorbic acid (Standard) (links to external site)
Cat. No. HY-B0166R