adalimumab

Ligand id: 4860

Name: adalimumab

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Classification
Compound class Antibody
Approved drug? Yes (FDA (2002), EMA (2003))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
International Nonproprietary Names
INN number INN
7860 adalimumab
Synonyms
D2E7 [5] | FKB327 | Humira®
Comments
Adalimumab is an anti-TNFα monoclonal antibody with immunosuppresive activity [5]. It was the first fully human monoclonal antibody drug approved by the FDA.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

X-ray structures of the apo and TNFα-bound Fab fragment of adalimumab have been deposited to the RCSB Protein Data Bank (IDs 4NYL and 3WD5 respectively).

Biosimilars:
NameTrade nameCompanyClinical PhaseIndicationsReferences
adalimumab-atto; ABP 501 Amjevita; AmgevitaAmgenApproved (2016 FDA, 2017 EMA)As per reference agent[7]
adalimumab-adbm; BI 695501CyltezoBoehringer IngelheimApproved (2017 FDA and EMA)As per reference agent 
ZRC-3197ExemptiaCadila HealthcareApproved (2015 India)Rheumatoid arthritis[1,3]
SB5; adalimumab-bwwdHadlimaSamsung BioepisApproved (2019 FDA)As per reference agent 
MSB11022Idacio; KromeyaFresenius KabiApproved (2019 EMA)As per reference agent
BCD-057 BiocadPh 3 (NCT02762955)Plaque psoriasis 
adalimumab-adaz; GP2017Hyrimoz; Hefiya; HalimatozSandozApproved (2018 EMA and FDA)As per reference agent [6]
M923 Momenta PharmaceuticalsPh 3 (NCT02581345)Plaque psoriasis, rheumatoid arthritis  
MYL-1401AHulioMylanApproved (EMA 2018)As per reference agent 
MSB11022 MerckPh 3 (NCT02660580)Plaque psoriasis, rheumatoid arthritis  
PF-06410293 PfizerPh 3 (NCT02480153)Rheumatoid arthritis 
FKB327 Fujifilm Kyowa Kirin BiologicsPh 3 (NCT02260791)Rheumatoid arthritis[8]
IBI303 Innovent BiologicsPh 3 (NCT02893254)Active ankylosing spondylitis
Database Links
Specialist databases
IMGT/mAb-DB 165
Other databases
GtoPdb PubChem SID 178101561
PubChem SID 178101561
Search PubMed clinical trials adalimumab
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Search PubMed titles/abstracts adalimumab
Wikipedia Adalimumab