bradykinin   Click here for help

GtoPdb Ligand ID: 649

Synonyms: BK | kallidin I | kinin 9
Comment: The rat, mouse and human sequences are identical.
Species: Human, Mouse, Rat
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES OCC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)O)CCCN=C(N)N)Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CCCN=C(N)N)N
Isomeric SMILES OC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCN=C(N)N)Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N
InChI InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI Key QXZGBUJJYSLZLT-FDISYFBBSA-N
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
IUPAC Name Click here for help
(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Synonyms Click here for help
BK | kallidin I | kinin 9
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
KNG1 kininogen 1 Human kininogen-1 precursor alpha-2-thiol proteinase inhibitor, BDK, bradykinin, kininogen, KNG
Kng1 kininogen 1 Mouse kininogen-1 precursor H-kininigen, L-kininogen
Kng2 kininogen 2 Rat kininogen-1 precursor alpha-1-MAP, kininogen, kininogen 1, kininogen 1, variant 1, KINKG, KINKH, KINT1G, K-kininogen, differential splicing leads to HMW Kngk, Kng, Kng1, Kng1_v1, Kngk, Kngt, Kngt1, Kng_v1, LMW T-kininogen I, major acute phase protein, Map1, MGC93589, RATKINKG, RATKINKH, RATKINT1G, RATTKG6, thiostatin, Tkg, TKG6, T-kininogen, T-kininogen 1, T-kininogen I, T-kininogen see also D11Elh1 and D11Mit8
Database Links Click here for help
ChEBI CHEBI:3165
ChEMBL Ligand CHEMBL406291
GtoPdb PubChem SID 135651637
PubChem CID 439201
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UniProtKB P01042 (Hs), O08677 (Mm), P08934 (Rn)
Wikipedia Bradykinin

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Tocris
Bradykinin
Cat. No. 3004