Urate anion exchanger 1 | Urate transporter | IUPHAR/BPS Guide to PHARMACOLOGY

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Urate anion exchanger 1

Target not currently curated in GtoImmuPdb

Target id: 1031

Nomenclature: Urate anion exchanger 1

Abbreviated Name: URAT1

Systematic Nomenclature: SLC22A12

Family: Urate transporter

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC22A12 solute carrier family 22 member 12
Mouse - - Slc22a12 solute carrier family 22 (organic anion/cation transporter)
Rat - - Slc22a12 solute carrier family 22 member 12
Previous and Unofficial Names
organic anion transporter 4-like protein | Renal-specific transporter | RST | OAT4L | solute carrier family 22 (organic anion/cation transporter), member 12 | solute carrier family 22 (organic anion/urate transporter), member 12 | solute carrier family 22 (organic anion/cation transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC22A12 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Stoichiometry
Unknown

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
sufinpyrazone Hs Inhibition 4.0 pIC50 2
pIC50 4.0 (IC50 1x10-4 M) [2]
lesinurad Hs Inhibition - -
verinurad Hs Inhibition - -
General Comments
URAT1 as a target for the treatment of hyperuricemia of gout is reviewed in [1].

References

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1. Diaz-TornĂ© C, Perez-Herrero N, Perez-Ruiz F. (2015) New medications in development for the treatment of hyperuricemia of gout. Curr Opin Rheumatol, 27 (2): 164-9. [PMID:25603039]

2. Yu Z, Fong WP, Cheng CH. (2007) Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug Metab. Dispos., 35 (6): 981-6. [PMID:17325024]

Contributors

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