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target has curated data in GtoImmuPdb
Target id: 1407
Nomenclature: PLCγ1
Family: Phosphoinositide-specific phospholipase C
Annotation status:
Awaiting annotation/under development. Please contact us if you can help with annotation.
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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1291 | 20q12 | PLCG1 | phospholipase C gamma 1 | |
Mouse | - | - | Plcg1 | phospholipase C, gamma 1 | ||
Rat | - | - | Plcg1 | phospholipase C, gamma 1 |
Database Links ![]() |
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BRENDA | 3.1.4.11 |
CATH/Gene3D | 2.30.29.30, 2.60.40.150, 3.20.20.190, 3.30.505.10 |
ChEMBL Target | CHEMBL3964 (Hs), CHEMBL5188 (Rn) |
Ensembl Gene | ENSG00000124181 (Hs), ENSMUSG00000016933 (Mm), ENSRNOG00000016340 (Rn) |
Entrez Gene | 5335 (Hs), 18803 (Mm), 25738 (Rn) |
Human Protein Atlas | ENSG00000124181 (Hs) |
KEGG Enzyme | 3.1.4.11 |
KEGG Gene | hsa:5335 (Hs), mmu:18803 (Mm), rno:25738 (Rn) |
OMIM | 172420 (Hs) |
RefSeq Nucleotide | NM_002660 (Hs) |
RefSeq Protein | NP_002651 (Hs) |
UniProtKB | P19174 (Hs), Q62077 (Mm), P10686 (Rn) |
Wikipedia | PLCG1 (Hs) |
Enzyme Reaction ![]() |
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Cofactors ![]() |
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Endogenous activators (Human) |
PIP3 [1] |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,4], although PLCγ1 may be the predominant isoform active in human mast cells [5]. |
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Immuno Process Associations | |||||||||||||||
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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273 (8): 4465-9. [PMID:9468499]
2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol., 6 (3): 218-30. [PMID:16470226]
3. Lee JS, Kim J, Kim BY, Lee HS, Ahn JS, Chang YS. (2000) Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. J. Nat. Prod., 63 (6): 753-6. [PMID:10869194]
4. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]
5. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J. Biol. Chem., 278 (48): 48474-84. [PMID:13129935]
Phosphoinositide-specific phospholipase C: PLCγ1. Last modified on 10/07/2018. Accessed on 13/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1407.