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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1407

Nomenclature: PLCγ1

Family: Phosphoinositide-specific phospholipase C

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1290 20q12 PLCG1 phospholipase C gamma 1
Mouse - 1302 2 80.97 cM Plcg1 phospholipase C, gamma 1
Rat - 1290 3q42 Plcg1 phospholipase C, gamma 1
Previous and Unofficial Names Click here for help
PLC1 | PLC148 | PLCgamma1 | phosphoinositide phospholipase C-gamma-1 | phospholipase C, gamma 1 | PPLCA | Cded | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | NCKAP3 | phospholipase C
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactors Click here for help
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3  [1]

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5 [PMID: 10869194] Small molecule or natural product Bt Inhibition 5.0 pIC50 3
pIC50 5.0 (IC50 9.5x10-6 M) [3]
Immunopharmacology Comments
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,4], although PLCγ1 may be the predominant isoform active in human mast cells [5].
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling


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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6 (3): 218-30. [PMID:16470226]

3. Lee JS, Kim J, Kim BY, Lee HS, Ahn JS, Chang YS. (2000) Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. J Nat Prod, 63 (6): 753-6. [PMID:10869194]

4. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

5. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem, 278 (48): 48474-84. [PMID:13129935]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ1. Last modified on 10/07/2018. Accessed on 28/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,