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PLCγ1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1407

Nomenclature: PLCγ1

Family: Phosphoinositide-specific phospholipase C

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1290 20q12 PLCG1 phospholipase C gamma 1
Mouse - 1302 2 80.97 cM Plcg1 phospholipase C, gamma 1
Rat - 1290 3q42 Plcg1 phospholipase C, gamma 1
Previous and Unofficial Names Click here for help
PLC1 | PLC148 | PLCgamma1 | phosphoinositide phospholipase C-gamma-1 | phospholipase C, gamma 1 | PPLCA | Cded | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | NCKAP3 | phospholipase C
Database Links Click here for help
Alphafold P19174 (Hs), Q62077 (Mm), P10686 (Rn)
BRENDA 3.1.4.11
CATH/Gene3D 2.30.29.30, 2.60.40.150, 3.20.20.190, 3.30.505.10
ChEMBL Target CHEMBL3964 (Hs), CHEMBL5188 (Rn)
Ensembl Gene ENSG00000124181 (Hs), ENSMUSG00000016933 (Mm), ENSRNOG00000016340 (Rn)
Entrez Gene 5335 (Hs), 18803 (Mm), 25738 (Rn)
Human Protein Atlas ENSG00000124181 (Hs)
KEGG Enzyme 3.1.4.11
KEGG Gene hsa:5335 (Hs), mmu:18803 (Mm), rno:25738 (Rn)
OMIM 172420 (Hs)
Pharos P19174 (Hs)
RefSeq Nucleotide NM_002660 (Hs)
RefSeq Protein NP_002651 (Hs)
UniProtKB P19174 (Hs), Q62077 (Mm), P10686 (Rn)
Wikipedia PLCG1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactors Click here for help
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3  [1]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5 [PMID: 10869194] Small molecule or natural product Bt Inhibition 5.0 pIC50 3
⤷ pIC50 5.0 (IC50 9.5x10-6 M) [3]
Immunopharmacology Comments
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,4], although PLCγ1 may be the predominant isoform active in human mast cells [5].
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002862 negative regulation of inflammatory response to antigenic stimulus TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050900 leukocyte migration TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002862 negative regulation of inflammatory response to antigenic stimulus TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway TAS

References

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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6 (3): 218-30. [PMID:16470226]

3. Lee JS, Kim J, Kim BY, Lee HS, Ahn JS, Chang YS. (2000) Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. J Nat Prod, 63 (6): 753-6. [PMID:10869194]

4. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

5. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem, 278 (48): 48474-84. [PMID:13129935]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ1. Last modified on 10/07/2018. Accessed on 20/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1407.