Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1291	20q12	PLCG1	phospholipase C gamma 1
Mouse	-	-		Plcg1	phospholipase C, gamma 1
Rat	-	-		Plcg1	phospholipase C, gamma 1

Previous and Unofficial Names

PLC1 | PLC148 | PLCgamma1 | phosphoinositide phospholipase C-gamma-1 | phospholipase C, gamma 1 | PPLCA | Cded | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | NCKAP3 | phospholipase C

Database Links
BRENDA	3.1.4.11
CATH/Gene3D	2.30.29.30, 2.60.40.150, 3.20.20.190, 3.30.505.10
ChEMBL Target	CHEMBL3964 (Hs), CHEMBL5188 (Rn)
Ensembl Gene	ENSG00000124181 (Hs), ENSMUSG00000016933 (Mm), ENSRNOG00000016340 (Rn)
Entrez Gene	5335 (Hs), 18803 (Mm), 25738 (Rn)
Human Protein Atlas	ENSG00000124181 (Hs)
KEGG Enzyme	3.1.4.11
KEGG Gene	hsa:5335 (Hs), mmu:18803 (Mm), rno:25738 (Rn)
OMIM	172420 (Hs)
RefSeq Nucleotide	NM_002660 (Hs)
RefSeq Protein	NP_002651 (Hs)
UniProtKB	P19174 (Hs), Q62077 (Mm), P10686 (Rn)
Wikipedia	PLCG1 (Hs)

Enzyme Reaction
EC Number: 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactors
Cofactor Species Comments Reference Ca2+ Human

Endogenous activators (Human)

PIP3  [1]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 5 [PMID: 10869194] Bt Inhibition 5.0 pIC50 3 ⤷ pIC50 5.0 (IC50 9.5x10-6 M) [3]

Immunopharmacology Comments

Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,4], although PLCγ1 may be the predominant isoform active in human mast cells [5].

Cell Type Associations

Immuno Cell Type:  Mast cells Cell Ontology Term:   mast cell (CL:0000097)

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 2 GO processes GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0050900 leukocyte migration TAS

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0050852 T cell receptor signaling pathway TAS

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0050900 leukocyte migration TAS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 3 GO processes GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0050852 T cell receptor signaling pathway TAS