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Target not currently curated in GtoImmuPdb
Target id: 1434
Nomenclature: PLD2
Family: Phosphatidylcholine-specific phospholipase D, Hydrolases & Lipases
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 933 | 17p13.2 | PLD2 | phospholipase D2 | |
| Mouse | - | 933 | 11 42.99 cM | Pld2 | phospholipase D2 | |
| Rat | - | 933 | 10q24 | Pld2 | phospholipase D2 | |
| Previous and Unofficial Names |
| Choline phosphatase 2 | PLD1C | phosphatidylcholine-hydrolyzing phospholipase D2 | phospholipase D2 |
| Database Links |
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| Alphafold | O14939 (Hs), P97813 (Mm), P70498 (Rn) |
| BRENDA | 3.1.4.4 |
| CATH/Gene3D | 2.30.29.30, 3.30.1520.10 |
| ChEMBL Target | CHEMBL2734 (Hs), CHEMBL3309055 (Mm) |
| Ensembl Gene | ENSG00000129219 (Hs), ENSMUSG00000020828 (Mm), ENSRNOG00000019604 (Rn) |
| Entrez Gene | 5338 (Hs), 18806 (Mm), 25097 (Rn) |
| Human Protein Atlas | ENSG00000129219 (Hs) |
| KEGG Enzyme | 3.1.4.4 |
| KEGG Gene | hsa:5338 (Hs), mmu:18806 (Mm), rno:25097 (Rn) |
| OMIM | 602384 (Hs) |
| Pharos | O14939 (Hs) |
| RefSeq Nucleotide | NM_002663 (Hs), NM_008876 (Mm), NM_033299 (Rn) |
| RefSeq Protein | NP_002654 (Hs), NP_032902 (Mm), NP_150641 (Rn) |
| UniProtKB | O14939 (Hs), P97813 (Mm), P70498 (Rn) |
| Wikipedia | PLD2 (Hs) |
| Enzyme Reaction |
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| Endogenous inhibitor (Human) |
| Gβγ [3] |
Download all structure-activity data for this target as a CSV file 
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1. Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem, 53 (18): 6706-19. [PMID:20735042]
2. Lopez I, Arnold RS, Lambeth JD. (1998) Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol Chem, 273 (21): 12846-52. [PMID:9582313]
3. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA. (2006) Direct modulation of phospholipase D activity by Gbetagamma. Mol Pharmacol, 70 (1): 311-8. [PMID:16638972]
4. Sarri E, Pardo R, Fensome-Green A, Cockcroft S. (2003) Endogenous phospholipase D2 localizes to the plasma membrane of RBL-2H3 mast cells and can be distinguished from ADP ribosylation factor-stimulated phospholipase D1 activity by its specific sensitivity to oleic acid. Biochem J, 369 (Pt 2): 319-29. [PMID:12374567]
5. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol, 5 (2): 108-17. [PMID:19136975]
