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Gene and Protein Information | ||||||
class A G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 404 | 12q13.3 | GPR182 | G protein-coupled receptor 182 | 2 |
Mouse | 7 | 395 | 10 75.07 cM | Gpr182 | G protein-coupled receptor 182 | |
Rat | 7 | 395 | 7q22 | Gpr182 | G protein-coupled receptor 182 |
Previous and Unofficial Names | |
ADMR | Gpcr17 | Gpcr22 | L1-R [12] | NOW |
Database Links | |
Specialist databases | |
GPCRdb | gp182_human (Hs), gp182_mouse (Mm), gp182_rat (Rn) |
Other databases | |
Alphafold | O15218 (Hs), P43142 (Mm), P31392 (Rn) |
ChEMBL Target | CHEMBL4356 (Hs) |
Ensembl Gene | ENSG00000166856 (Hs), ENSMUSG00000058396 (Mm), ENSRNOG00000004311 (Rn) |
Entrez Gene | 11318 (Hs), 11536 (Mm), 29307 (Rn) |
Human Protein Atlas | ENSG00000166856 (Hs) |
KEGG Gene | hsa:11318 (Hs), mmu:11536 (Mm), rno:29307 (Rn) |
OMIM | 605307 (Hs) |
Pharos | O15218 (Hs) |
RefSeq Nucleotide | NM_007264 (Hs), NM_007412 (Mm), NM_053302 (Rn) |
RefSeq Protein | NP_009195 (Hs), NP_031438 (Mm), NP_445754 (Rn) |
UniProtKB | O15218 (Hs), P43142 (Mm), P31392 (Rn) |
Wikipedia | GPR182 (Hs) |
Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Agonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
Rat GPR182 was first proposed as adrenomedullin receptor [5]. However, it was later reported that rat and human GPR182 did not respond to adrenomedullin [6]. |
Tissue Distribution | ||||||||
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Tissue Distribution Comments | ||||||||
It is reported that the expression level of GPR182 in mouse embryonic tissue was low at 7 and 11 d.p.c, but drastically increased by 15 d.p.c. and stayed high until 17 d.p.c. [13]. In contrast to the previous report [10], Yotsumoto et al. did not detect the expression of GPR182 in the giant trophoblastic cells by Northern blot analyses [13]. It is found that the expression pattern of GPR182 in human tissue is considerably different from that of rat tissues [2]. |
Expression Datasets | |
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Physiological Functions | ||||||||
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Physiological Consequences of Altering Gene Expression | ||||||||||
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Gene Expression and Pathophysiology Comments | |
It is proposed that adrenomedullin/GPR182 may involve in respiratory physiology and lung carcinogenesis [8]. |
Biologically Significant Variants | ||||||||||||||||
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1. Harrison JK, Barber CM, Lynch KR. (1993) Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver. FEBS Lett, 318 (1): 17-22. [PMID:8382168]
2. Hänze J, Dittrich K, Dötsch J, Rascher W. (1997) Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. Biochem Biophys Res Commun, 240 (1): 183-8. [PMID:9367907]
3. Jahnke GD, Miller MJ, Martínez A, Montuenga L, Cuttitta F. (1997) Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk. J Mol Endocrinol, 19 (3): 279-89. [PMID:9460649]
4. Jiménez N, Calvo A, Martínez A, Rosell D, Cuttitta F, Montuenga LM. (1999) Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate. J Histochem Cytochem, 47 (9): 1167-78. [PMID:10449538]
5. Kapas S, Catt KJ, Clark AJ. (1995) Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J Biol Chem, 270 (43): 25344-7. [PMID:7592696]
6. Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ. (1998) Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. Biochem Biophys Res Commun, 244 (3): 832-7. [PMID:9535752]
7. Martínez A, Elsasser TH, Muro-Cacho C, Moody TW, Miller MJ, Macri CJ, Cuttitta F. (1997) Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument. Endocrinology, 138 (12): 5597-604. [PMID:9389548]
8. Martínez A, Miller MJ, Catt KJ, Cuttitta F. (1997) Adrenomedullin receptor expression in human lung and in pulmonary tumors. J Histochem Cytochem, 45 (2): 159-64. [PMID:9016306]
9. Miller MJ, Martínez A, Unsworth EJ, Thiele CJ, Moody TW, Elsasser T, Cuttitta F. (1996) Adrenomedullin expression in human tumor cell lines. Its potential role as an autocrine growth factor. J Biol Chem, 271 (38): 23345-51. [PMID:8798536]
10. Montuenga LM, Martínez A, Miller MJ, Unsworth EJ, Cuttitta F. (1997) Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Endocrinology, 138 (1): 440-51. [PMID:8977434]
11. Ramachandran V, Arumugam T, Hwang RF, Greenson JK, Simeone DM, Logsdon CD. (2007) Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR. Cancer Res, 67 (6): 2666-75. [PMID:17363587]
12. Ramachandran V, Arumugam T, Langley R, Hwang RF, Vivas-Mejia P, Sood AK, Lopez-Berestein G, Logsdon CD. (2009) The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment. PLoS ONE, 4 (10): e7502. [PMID:19847298]
13. Yotsumoto S, Shimada T, Cui CY, Nakashima H, Fujiwara H, Ko MS. (1998) Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse. Dev Biol, 203 (2): 264-75. [PMID:9808778]