protein kinase, cAMP-dependent, regulatory, type I, alpha subunit | Protein kinase A (PKA) family | IUPHAR/BPS Guide to PHARMACOLOGY

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protein kinase, cAMP-dependent, regulatory, type I, alpha subunit

Target not currently curated in GtoImmuPdb

Target id: 1472

Nomenclature: protein kinase, cAMP-dependent, regulatory, type I, alpha subunit

Abbreviated Name: PKAR1A

Family: Protein kinase A (PKA) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
protein kinase A
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 381 17q23-q24 PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha
Mouse - 381 11 E1 Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha
Rat - 381 10q32.1 Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha
Previous and Unofficial Names
TSE1 | tissue specific extinguisher 1 | protein kinase, cAMP dependent regulatory, type I, alpha | RIIA | RIalpha | PRKAR1 | protein kinase, cAMP-dependent, regulatory subunit type I alpha | protein kinase | protein kinase cAMP-dependent type 1 regulatory subunit alpha
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Clinically-Relevant Mutations and Pathophysiology
Disease:  Acrodysostosis 1 with or without hormone resistance; ACRDYS1
Synonyms: Acrodysostosis [Orphanet: ORPHA950] [Disease Ontology: DOID:14669]
Acrodysostosis with multiple hormone resistance [Orphanet: ORPHA280651]
Disease Ontology: DOID:14669
OMIM: 101800
Orphanet: ORPHA950, ORPHA280651
Disease:  Carney complex, type 1; CNC1
Synonyms: Carney complex [Orphanet: ORPHA1359] [Disease Ontology: DOID:0050471]
Disease Ontology: DOID:0050471
OMIM: 160980
Orphanet: ORPHA1359
Disease:  Myxoma, intracardiac
OMIM: 255960
Orphanet: ORPHA615
Disease:  Pigmented nodular adrenocortical disease, primary, 1; PPNAD1
Synonyms: Primary pigmented nodular adrenocortical disease [Orphanet: ORPHA189439]
OMIM: 610489
Orphanet: ORPHA189439

How to cite this page

Protein kinase A (PKA) family: protein kinase, cAMP-dependent, regulatory, type I, alpha subunit. Last modified on 11/03/2014. Accessed on 12/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1472.