Quaternary Structure: Complexes

Interleukin-11 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	422	9p13.3	IL11RA	interleukin 11 receptor subunit alpha
Mouse	1	432	4 21.94 cM	Il11ra1	interleukin 11 receptor subunit alpha 1
Rat	1	431	5q22	Il11ra1	interleukin 11 receptor subunit alpha 1

Previous and Unofficial Names

Il11ra | NR1 | interleukin 11 receptor, alpha | interleukin 11 receptor

Database Links
Alphafold	Q14626 (Hs), Q64385 (Mm), Q99MF4 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL2050 (Hs)
DrugBank Target	Q14626 (Hs)
Ensembl Gene	ENSG00000137070 (Hs), ENSMUSG00000073889 (Mm), ENSRNOG00000015068 (Rn)
Entrez Gene	3590 (Hs), 16157 (Mm)
Human Protein Atlas	ENSG00000137070 (Hs)
KEGG Gene	hsa:3590 (Hs), mmu:16157 (Mm)
OMIM	600939 (Hs)
Orphanet	ORPHA284155 (Hs)
Pharos	Q14626 (Hs)
UniProtKB	Q14626 (Hs), Q64385 (Mm), Q99MF4 (Rn)
Wikipedia	IL11RA (Hs)

Agonist Comments

Interleukin-11 receptor, α subunit is the primary target of the approved drug oprelvekin, a recombinant form of IL-11.

Immunopharmacology Comments

This is the ligand-binding component of the functional receptor for interleukin 11.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  Immune system development

Clinically-Relevant Mutations and Pathophysiology
Disease:  Craniosynostosis and dental anomalies OMIM: 614188 Orphanet: ORPHA284149