Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	508	19p13.2	EPOR	erythropoietin receptor
Mouse	1	507	9 7.93 cM	Epor	erythropoietin receptor
Rat	1	507	8q13	Epor	erythropoietin receptor

Previous and Unofficial Names

EPO-R | erythropoietin receptor

Database Links
Alphafold	P19235 (Hs), P14753 (Mm), Q07303 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL1817 (Hs)
DrugBank Target	P19235 (Hs)
Ensembl Gene	ENSG00000187266 (Hs), ENSMUSG00000006235 (Mm), ENSRNOG00000012619 (Rn)
Entrez Gene	2057 (Hs), 13857 (Mm), 24336 (Rn)
Human Protein Atlas	ENSG00000187266 (Hs)
KEGG Gene	hsa:2057 (Hs), mmu:13857 (Mm), rno:24336 (Rn)
OMIM	133171 (Hs)
Orphanet	ORPHA121581 (Hs)
Pharos	P19235 (Hs)
UniProtKB	P19235 (Hs), P14753 (Mm), Q07303 (Rn)
Wikipedia	EPOR (Hs)

Selected 3D Structures
	Description:  Crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms PDB Id:  1EER Ligand:  erythropoietin Resolution:  1.9Å Species:  Human References:  5

Natural/Endogenous Ligands
erythropoietin {Sp: Human}

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Agonists
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference erythropoietin {Sp: Human} Hs Agonist 11.1 pIC50 3 ⤷ pIC50 11.1 (IC50 7x10-12 M) [3] Description: Assay performed using recombinant human EPO peginesatide Hs Agonist 10.4 pIC50 3 ⤷ pIC50 10.4 (IC50 3.7x10-11 M) [3] cibinetide Hs Agonist - - 2 ⤷ [2]

Immunopharmacology Comments

A non-hematopoietic EPOR-containing receptor, called the innate repair receptor (IRR) or tissue-protective receptor, down-modulates the damaging effects of the immune response to tissue injury [1]. This EPO-mediated tissue-protective system acts via a heterodimeric receptor composed of the EPOR and the cytokine receptor β common receptor subunit (CD131) [1]. IRR is not normally expressed by normal tissues. Its expression is rapidly upregulated by tissue injury, inflammation and hypoxia. This system acts as a compensatory protective response in tissues exposed to tumor necrosis factor (TNF)-α and other proinflammatory cytokines that are released at sites of tissue insult, and promotes tissue recovery. Synthetic peptides that selectively activate the IRR (i.e. that do not activate the hematopoietic receptor responsible for erythropoiesis and are devoid of hematopoietic and thrombotic effects) are being developed for their potential tissue-protective and damage-mitigating effects in a number of pathological settings [4]- see cibinetide as an example.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Erythrocytosis, familial, 1; ECYT1 Synonyms: Primary familial polycythemia [Orphanet: ORPHA90042] OMIM: 133100 Orphanet: ORPHA90042

General Comments

The EPO/EPOR sytem is responsible for erythropoiesis and has an endogenous tissue protective role. The classical hematopoietic EPO receptor is a homodimer of two EPOR subunits. A non-hematopoietic EPOR-containing receptor, called the innate repair receptor (IRR) or tissue-protective receptor exists, and structurally this is a heterodimer composed of the EPOR and the cytokine receptor β common receptor subunit (CD131) [1].