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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 635 | 1p34.2 | MPL | MPL proto-oncogene, thrombopoietin receptor | |
Mouse | 1 | 625 | 4 54.61 cM | Mpl | myeloproliferative leukemia virus oncogene | |
Rat | - | - | 5q36 | Mpl | MPL proto-oncogene, thrombopoietin receptor |
Previous and Unofficial Names |
CD110 | MPL | Myeloproliferative leukemia protein | TPOR | MPL proto-oncogene, thrombopoietin receptor | MPL proto-oncogene |
Database Links | |
Alphafold | P40238 (Hs), Q08351 (Mm) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL1864 (Hs), CHEMBL1075309 (Mm) |
DrugBank Target | P40238 (Hs) |
Ensembl Gene | ENSG00000117400 (Hs), ENSMUSG00000006389 (Mm), ENSRNOG00000028377 (Rn) |
Entrez Gene | 4352 (Hs), 17480 (Mm), 366455 (Rn) |
Human Protein Atlas | ENSG00000117400 (Hs) |
KEGG Gene | hsa:4352 (Hs), mmu:17480 (Mm), rno:366455 (Rn) |
OMIM | 159530 (Hs) |
Orphanet | ORPHA123465 (Hs) |
Pharos | P40238 (Hs) |
UniProtKB | P40238 (Hs), Q08351 (Mm) |
Wikipedia | MPL (Hs) |
Natural/Endogenous Ligands |
thrombopoietin {Sp: Human} |
Download all structure-activity data for this target as a CSV file
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||
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1. Fukushima-Shintani M, Suzuki K, Iwatsuki Y, Abe M, Sugasawa K, Hirayama F, Kawasaki T, Nakahata T. (2009) AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol, 82 (4): 247-54. [PMID:19183407]
2. Marsilje TH, Alper PB, Lu W, Mutnick D, Michellys PY, He Y, Karanewsky DS, Chow D, Gerken A, Lao J et al.. (2008) Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold. Bioorg Med Chem Lett, 18 (19): 5259-62. [PMID:18783949]
3. Yoshida H, Yamada H, Nogami W, Dohi K, Kurino-Yamada T, Sugiyama K, Takahashi K, Gahara Y, Kitaura M, Hasegawa M et al.. (2018) Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl. Exp Hematol, 59: 30-39.e2. [PMID:29274361]
Prolactin receptor family: Thrombopoietin receptor. Last modified on 07/02/2020. Accessed on 07/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722.