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receptor tyrosine kinase like orphan receptor 1

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Target not currently curated in GtoImmuPdb

Target id: 1845

Nomenclature: receptor tyrosine kinase like orphan receptor 1

Abbreviated Name: ROR1

Family: Type VIII RTKs: ROR family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 937 1p31.3 ROR1 receptor tyrosine kinase like orphan receptor 1
Mouse 1 937 4 45.71 cM Ror1 receptor tyrosine kinase-like orphan receptor 1
Rat - 937 5q33 Ror1 receptor tyrosine kinase-like orphan receptor 1
Previous and Unofficial Names Click here for help
NTRKR1 | neurotrophic tyrosine kinase, receptor-related 1
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.10.1
General Comments
ROR1 is overexpressed by a variety of solid and hematological cancers (e.g. a subset of non-small cell lung cancer, triple-negative breast, pancreatic , and prostate cancers, B cell chronic lymphocytic leukemia and mantle cell lymphoma) and it is being investigated as a molecular target for therapeutic potential in ROR1 positive cancers. For example, VelosBio have an anti-ROR1 antibody drug conjugate (VLS-101) in Phase 2 trial as monotherapy for ROR1 positive cancers (NCT04504916). The toxic payload delivered by VLS-101 is the microtubule disrupting cytotoxin, monomethyl auristatin E (MMAE). In November 2020 Merck bought VelosBio. Juno Therapeutics (part of Bristol Myers Squibb) are taking a different route to target ROR1, with their ROR1-targeting (CAR) T-cells in clinical trial NCT02706392.

How to cite this page

Type VIII RTKs: ROR family : receptor tyrosine kinase like orphan receptor 1. Last modified on 06/11/2020. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1845.