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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1885

Nomenclature: TACI

Systematic Nomenclature: TNFRSF13B

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 293 17p11.2 TNFRSF13B TNF receptor superfamily member 13B
Mouse 1 249 11 B2 Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b
Rat - - Tnfrsf13b TNF receptor superfamily member 13B
Previous and Unofficial Names Click here for help
CD267 | tumor necrosis factor receptor superfamily, member 13B | Transmembrane activator and CAML interactor | tumor necrosis factor receptor superfamily member 13B | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 13b
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands Click here for help
APRIL {Sp: Human}
BAFF {Sp: Human}
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
APRIL {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs - - -
BAFF {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs - - -
Immunopharmacology Comments
TACI is a lymphocyte-specific TNF superfamily receptor expressed on B cells. Endogenous ligands include APRIL, BAFF and CAML. Defects in the function of TACI can underlie immunodeficiencies and autoimmune diseases. TACI ligands are molecular targets of approved and investigational biologics that are intended to treat B cell-mediated immune system defects
Immuno Process Associations
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Immuno Process:  T cell (activation)
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Common variable immunodeficiency
Description: CVID is a group of genetically heterogeneous primary immunodeficiencies. Whilst a small number of cases can be linked to deficiency in a single gene (see the OMIM links as examples), the cause is likely to be polygenic in the majority of cases. Symptoms vary between patients, but CVID is generally characterised by a failure to produce antibodies (hypogammaglobulinemia) and therefore susceptibility to recurrent infections and inflammation (including autoimmunity).
Disease Ontology: DOID:12177
OMIM: 613495, 607594, 606453, 240500, 613493
Orphanet: ORPHA1572
References:  1-2


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1. Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS. (2005) TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet, 37 (8): 829-34. [PMID:16007086]

2. Salzer U, Chapel HM, Webster AD, Pan-Hammarström Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schäffer AA et al.. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet, 37 (8): 820-8. [PMID:16007087]


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