Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	283	1p36.32	TNFRSF14	TNF receptor superfamily member 14
Mouse	-	-		Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Rat	-	-		Tnfrsf14	TNF receptor superfamily member 14

Previous and Unofficial Names

ATAR | Herpesvirus entry mediator A | HVEA | HVEM | TR2 | tumor necrosis factor receptor superfamily, member 14 | CD270 | LIGHTR | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

Database Links
Alphafold	Q92956 (Hs)
Ensembl Gene	ENSG00000157873 (Hs), ENSMUSG00000042333 (Mm), ENSRNOG00000013820 (Rn)
Entrez Gene	8764 (Hs), 230979 (Mm), 366518 (Rn)
Human Protein Atlas	ENSG00000157873 (Hs)
KEGG Gene	hsa:8764 (Hs), mmu:230979 (Mm), rno:366518 (Rn)
OMIM	602746 (Hs)
Pharos	Q92956 (Hs)
UniProtKB	Q92956 (Hs)
Wikipedia	TNFRSF14 (Hs)

Natural/Endogenous Ligands
B and T lymphocyte attenuator {Sp: Human}
LIGHT {Sp: Human}
lymphotoxin-α {Sp: Human}

Adaptor proteins (Human)

TRAF2, TRAF3, TRAF5

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference B and T lymphocyte attenuator {Sp: Human} Hs - - - ⤷ lymphotoxin-α {Sp: Human} Hs - - - ⤷ LIGHT {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

HSV viral envelope glycoprotein D (gD) binds to this protein and thereby gains entry to the cell. HVEM binds to several TRAFadaptor proteins to mediate intracellular signalling and activation of the immune response.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  T cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Chemotaxis & migration

Immuno Process:  B cell (activation)

Immuno Process:  Cellular signalling

Immuno Process:  Barrier integrity