IL-1 receptor accessory protein

Target id: 1897

Nomenclature: IL-1 receptor accessory protein

Quaternary Structure: Complexes
Interleukin-1 receptor, type I
Interleukin-33 receptor
Interleukin-36 receptor
Interleukin-1 receptor, type II
Quaternary Structure Comments
IL1RAP is an accessory protein subunit of the functional receptors for IL-1, IL-33 and IL-36. It is a component in three signalling pathways that involve six IL-1 family cytokines (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ).
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human - 550 3q28 IL1RAP interleukin 1 receptor accessory protein
Mouse - 550 16 18.21 cM Il1rap interleukin 1 receptor accessory protein
Rat - 550 11q22 Il1rap interleukin 1 receptor accessory protein
Previous and Unofficial Names
IL1R3
IL-1R3
Database Links
CATH/Gene3D 3.40.50.10140, 2.60.40.10
Ensembl Gene ENSG00000196083 (Hs), ENSMUSG00000022514 (Mm), ENSRNOG00000001928 (Rn)
Human Protein Atlas ENSG00000196083 (Hs)
OMIM 602626 (Hs)
Pharos Q9NPH3 (Hs)
UniProtKB Q9NPH3 (Hs), Q61730 (Mm), Q63621 (Rn)
Wikipedia IL1RAP (Hs)
Protein Comments
An anti-IL1RAP monoclonal antibody (CAN04, nidanilimab) has been designed by Cantargia as a novel immunomodulator and it is being evaluated for potential antineoplastic efficacy in patients with solid malignant tumours (Phase 1/2 NCT03267316). CAN04 activates the immune system's killer cells and blocks proliferation signals that promote tumour growth. MAB-hR3, an antagonistic monoclonal antibody that targets IL1RAP inhibits signalling via all three of the signalling pathways in which IL1RAP is a co-receptor, is predicted to offer a novel broad spectrum anti-inflammatory agent for potential treatment of autoimmune and inflammatory diseases, with preclinical evidence provided by a mouse equivalent to MAB-hR3 which attenuates inflammation in in vivo models of inflammatory diseases that are driven by distinct subsets of the IL-1 family cytokines [1].

References

Show »

1. Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M et al.. (2019) IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease. Nat. Immunol., 20 (9): 1138-1149. [PMID:31427775]

How to cite this page

IL-1 receptor accessory protein. Last modified on 26/08/2019. Accessed on 24/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1897.