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Interleukin-10 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1900

Nomenclature: Interleukin-10 receptor

Family: IL-10 receptor family

Quaternary Structure: Subunits
Interleukin 10 receptor, α subunit (Ligand-binding subunit)
Interleukin 10 receptor, β subunit (Other subunit)
Natural/Endogenous Ligands Click here for help
IL-10 {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
IL-10 {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
Immunopharmacology Comments
The IL-10 receptor is a heteromeric complex containing two ligand binding α subunits (IL10RA) and two signal-transducing β subunits (IL10RB) [1]. Ligand binding leads to JAK/STAT signalling.

References

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1. Mosser DM, Zhang X. (2008) Interleukin-10: new perspectives on an old cytokine. Immunol. Rev., 226: 205-18. [PMID:19161426]

How to cite this page

IL-10 receptor family: Interleukin-10 receptor. Last modified on 10/04/2017. Accessed on 01/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1900.